KMID : 0378120020290020072
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Chungnam Medical Journal 2002 Volume.29 No. 2 p.72 ~ p.82
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Effect of Alendronate for Postmenopausal Osteoporosis according to BMI
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Jo Young-Suk
Na So-Young Lee Hyo-Jin Hong Woo-Jeong Kim Koon-Soon Kim Do-Hee Ku Bon-Jeong Shong Min-Ho Kim Young-Kun Ro Heung-Kyu
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Abstract
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Postmenopausal osteoporosis is a serious health problem. The aminophosphonate Alendronate is widely used for treatment of postmenopausal osteoporosis. We studied the effect of l0§· of alendronate given daily for mean 12 months on bone mineral density in 35 women(mean age 61yrs. mean BMI 23.24§¸/m^(2)) with osteoporosis. An over weight group is defined such that BMI was above 23§¸/m^(2). All the women received 1500§· calcium carbonate daily. The bone mineral density of L-spine and femoral neck was measured by dual-energy X-ray absorptiometry. Alendronate increased BMD at mean 12 months at the L-spine (7.15¡¾4.5%) and femoral neck(3.05¡¾2.86%) in normal women. Alendronate increased bone mineral density at 12 months at the L-spine(6.00¡¾5.3%) and femoral neck(4.17¡¾4.87%) in overweight women.
There was no difference between two groups. In the less than 7 years group of postmenopausal duration. alendronate increased bone mineral density at 12 months at the L-spine(6.9¡¾4.9%) and femoral neck(3.18¡¾7.1%). In the more than 7 years group of postmenopausal duration, alendronate increased hone mineral density at 1% months at the L-spine(6.5¡¾5.3%) and femoral neck(5.71¡¾0.08%). There was no difference between two groups. In postmenopausal women with osteoporosis, therapy with alendronate produced significant increases in BMD of the L-spine and femoral neck in both group. There was no difference between normal and over-weight groups. and between less than 7 years group and more than 7 years group of postmenopausal duration.
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KEYWORD
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Postmenopausal osteoporosis, Body mass index, Alendronate
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